The temperatures used in my home tobacco kiln fluctuate between 123°F and 128°F [~50°C to ~53°C] (for two months). At these temperatures, there is no vegetative fungal growth, and likely little growth of bacteria common to my tobacco growing environment.
View attachment 35108~
courses.lumenlearning.com
These kilning temperatures may not be sufficient to kill the organisms, but they cannot proliferate and actively ferment anything. [Some hard cheeses are often made using thermophilic cultures.] Under these kiln conditions, and within the "hot" center of pilones (piled tobacco bulks), the primary fermentative process is mediated by the leaf's intrinsic enzymes.
By contrast, low temperature tobacco fermentation (typically under pressure) does allow microbial growth and microbe mediated fermentative processes. This is what we see with pressed tobacco at ambient temperatures (below ~90°F). The array of microbial species that proliferate is random and extensive. [Perique processing is similar, but carried out beneath a liquid seal, thus maintaining an anaerobic (oxygen-free) environment, and selecting specifically for
Pichia anomala and likely other related yeast species, which yield characteristic perique.]
Here is a study from 1944 on low-temperature fermentation of tobacco.
This may be more applicable to cellaring pipe blends.
Bob