The effect of most virus infections on tobacco plants depends on when during the growing season the plant is infected. Infection of a new transplant usually results in serious impact to growth. Infection in mid-season or later will often simply injure one or a few leaves. The tobacco is still smokable. I have watched for spread to adjacent leaves or adjacent plants, and have not seen that. In general, virus infections depend on a vector for transmission. Insect vectors peak at specific times. Human vectors (carrying TMV, for example, on fingers or tools) tend to be sporadic in their behavior.
For me, tobacco virus infections have meant only that the productivity of the affected plants is somewhat reduced. I rarely pull out a plant, or even remove an affected leaf.
Bob
EDIT: I should add that when I am removing suckers, I remove them from a virus infected plant last. Then I wash my hands.