Nicotiana tabacum is an allotetraploid, derived from a chance crossing of two other (diploid, non-tabacum) species of Nicotiana: N. tomentosa and N. sylvestris. It's all been sort of mapped. There are many duplicated sequences scattered about. [Hey, Arabidopsis, can you spare a dime?] I would invite you to have a look at the links under Tobacco History, in our Index of Key Forum Threads. The tobacco residues found in archeological digs are often just barely identifiable as tobacco.
If you (and everyone else in your house) are anosmic, [or if you have an indoor cat], then growing indoor N. rustica may not present a problem. Otherwise, someone might observe that the growing plant smells like cat urine. I would suggest a Basma-type tobacco in a relatively small (6-8") pot (to limit its height to about 3'), for indoor growing. Their leaves are relatively small, and the plant is columnar, rather than pyramidal. The blossom heads are also tidier. The leaves will mature and ripen each year, so you will need to lop off the stalk above the lowest leaf axil each Spring, and grow a new sucker each year. Otherwise it will grow into a messy bush of suckers.
Nobody tastes flavors and aromas. Only the nose knows those. Your experimentation should be interesting to follow. Some cigar smokers, including myself, find that smoking a cigar in the dark, where you cannot observe the smoke wafting, is not as enjoyable as smoking a cigar in the light. [Coffee tastes worse in a blue cup than in a brown cup!] So there are many factors at play.
Bob